Endocrine Abstracts

BackgroundEctopic ACTH syndrome (EAS) is a rare cause of endogenous hypercortisolism.ObjectiveTo analyze clinical, biochemical features and treatment outcomes of patients with EAS.Materials and methodsRetrospective, observational study on 129 patients (79 women, 50 men) with EAS diagnosed between 1990 and 2020. Plasma levels of ACTH (reference range: morning 7.2&#...

ObjectivesTo assess diagnostic and prognostic markers of permanent and transient postoperative diabetes insipidus.Patients and methodsThe study included 152 patients undergone endoscopic endonasal transsphenoidal surgery aged from 18 to 65 years with median 40 [31; 52] years. Seventy three patients had Cushing disease, 66 – acromegaly, 4 – prolactinoma, 9 – hormonally inactive adenoma, 1 –...

Objective: Differences in body weight and clinical features of typical vs atypical anorexia nervosa (A.N) might be explained by the genetic background. We aimed to evaluate the association between the subtypes of A.N. and the genetic polymorphisms of the thrombotic panel or the methyltetrahydrofolate reductase (MTHFR) gene.Methods: A total of 40 adolescent girls with A.N., aged 13–19 years, were evaluated. We recorded anthropometric parameters, amen...

Introduction: 21-hydroxylase deficiency (21-OHD) is a common inherited disorder accounting for 90–95% of congenital adrenal hyperplasia (CAH) cases. Some cases may be diagnosed in adulthood after the incidental discovery of adrenal masses on computerized tomography (CT).Case report: A 59-year-old male was investigated for incidentally discovered bilateral adrenal masses in an abdomen CT scan, measuring 5 cm on the right and 8 cm on the left adrenal....

Introduction: Diagnostic and post-therapy radioiodine whole body scan (WBS) is used in the follow-up of differentiated thyroid carcinoma (DTC) for the detection of local recurrence or remote metastasis. We report a case of false-positive uptake of radioiodine WBS.Case report: A 37-year-old female patient underwent subtotal thyroidectomy for multinodular goitre and histology revealed multifocal papillary thyroid carcinoma, of follicular type with three fo...

Introduction: Patient’s nutrition is generally considered to be the main cause of the accumulation of excess body weight. However, this accumulation can be mitigated by treatment involving drugs with a central mechanism of action. By using functional Magnetic Resonance Imaging (fMRI) we can meliorate our understanding of the organization of neuronal networks responsible for eating behavior, and see how they respond to the mechanisms of action of sibutramine in the treatm...

Background: Cancer of thyroid gland is rare in childhood, representing 1% of all pediatric malignancies. Primary thyroid lymphoma (PTL) is even rarer accounting for 5% of thyroid malignancies and 2% of extranodal lymphomas. The disease affects mainly adults in thesixth orseventh decade of life, with a female predominance. Most thyroid lymphomas are non-Hodgkin’s lymphomas (nHL) of B-cell origin. The most common type is Diffuse Large B- cell Lymphoma (DLBCL). Patients wit...

Introduction: The coexistence of papillary thyroid cancer (PTC) and medullary TC (MTC) is rare. Previous retrospective studies have shown a prevalence up to 19%. The aim of our study was to assess the prevalence of PTC in patients with sporadic MTC.Methods: This is a single-center retrospective study of an endocrinology outpatient clinic at a Tertiary, General, University Hospital. Patients who had undergone total thyroidectomy with central neck compartm...

Background: While the association between cigarette smoking and type 2 diabetes is established, the impact of smoking on developing gestational diabetes mellitus (GDM) remains controversial.Aim: To investigate whether maternal cigarette smoking during pregnancy is a risk factor for developing GDM.Methods: MEDLINE, Scopus, CENTRAL and Google Scholar databases were searched from inception to December 2022 to identify eligible origina...

Objective: To evaluate the association between genetic background and the presence of oligo- or amenorrhea in a sample of adolescent girls diagnosed with anorexia nervosa compared with controls.Methods: A total of 40 adolescent girls diagnosed with anorexia nervosa aged 14–17 years, as well as 10 age-matched girls, were included in the study. We recorded anthropometric parameters and calculated body mass index (BMI) z-scores adjusted for age, as wel...